Terence Wong

Overview:

1. Oncologic Imaging: PET/CT, novel PET radiotracers

2. Radionuclide therapy of cancer, Radiation Therapy Planning

3. Image-guided radiation therapy treatment planning

4. Hyperthermia

Positions:

Professor of Radiology

Radiology, Nuclear Medicine
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Education:

M.D. 1990

Dartmouth College

Ph.D. 1990

Dartmouth College

Fellow, Interventional & Intraoperative Mri

Children's Hospital, Boston

Grants:

Phase II Study of 44Gy from 131I-81C6 for CNS Tumors

Administered By
Neurosurgery, Neuro-Oncology
Awarded By
National Institutes of Health
Role
Co Investigator
Start Date
End Date

Radiation-Induced Cardiopulmonary Injury in Humans

Administered By
Radiation Oncology
Awarded By
National Institutes of Health
Role
Investigator
Start Date
End Date

Predicting Human Tumor Response by 31p MRS

Administered By
Radiology, Neuroradiology
Awarded By
National Institutes of Health
Role
Co Investigator
Start Date
End Date

Simultaneous Emission and Transmission Mammotomography

Administered By
Radiology
Awarded By
National Institutes of Health
Role
Investigator
Start Date
End Date

ECOG-ACRIN Operations Center Grant

Administered By
Radiology, Nuclear Medicine
Role
Principal Investigator
Start Date
End Date

Publications:

MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations.

PURPOSE: The purpose of the study was to evaluate the feasibility and protocol optimization of whole-body hybrid MR-PET system performed 1-month after post-locoregional thermoablative procedures for hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: Eight patients (6 men and 2 women; mean age, 56.6 ± 5.5 years) with 9 ablated HCCs constituted our study population. Three readers interpreted the studies to determine the presence or absence of residual malignancy. Two readers independently assessed the fused MR-PET images to compare registration accuracy of two types of T2-weighted (triggered T2 half-Fourier acquisition single-shot turbo spin-echo and turbo spin-echo) and T1-weighted [Cartesian and radial 3D gradient echo (GRE)]. Image quality evaluation of both 3D-GRE T1-weighted sequences was evaluated. Kappa statistics were used to measure inter-observer agreement. Non-parametric Kruskal-Wallis and Wilcoxon signed-rank tests were used for qualitative data analysis. RESULTS: Definite residual tumor was observed in 3/9 ablations; two were PET positive. All residual tumors were isovascular on MRI. Radial 3D-GRE demonstrated significantly superior MR-PET subjective co-registration in comparison with the remaining sequences and showed a non-significant trend toward higher image quality scores than Cartesian GRE. CONCLUSION: Whole-body hybrid MR-PET is feasible as a part of 1-month follow-up post-locoregional thermoablative treatment for HCC. Radial 3D-GRE offers improved co-registration with PET data, with overall good image quality.
Authors
Ramalho, M; AlObaidy, M; Burke, LM; Dale, BM; Gerber, DA; Wong, TZ; Semelka, RC
MLA Citation
Ramalho, Miguel, et al. “MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations..” Abdom Imaging, vol. 40, no. 6, Aug. 2015, pp. 1405–14. Pubmed, doi:10.1007/s00261-015-0436-6.
URI
https://scholars.duke.edu/individual/pub1345010
PMID
25906343
Source
pubmed
Published In
Abdom Imaging
Volume
40
Published Date
Start Page
1405
End Page
1414
DOI
10.1007/s00261-015-0436-6

R. Edward Coleman, MD, 1943-2012.

Authors
Turkington, T; Wong, T
MLA Citation
Turkington, Timothy, and Terence Wong. “R. Edward Coleman, MD, 1943-2012..” J Nucl Med, vol. 53, no. 8, Aug. 2012, pp. 16N-17N.
URI
https://scholars.duke.edu/individual/pub802978
PMID
22855841
Source
pubmed
Published In
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Volume
53
Published Date
Start Page
16N
End Page
17N

Utilization of (111)In-Capromab pendetide SPECT-CT for detecting seminal vesicle invasion with recurrent prostate cancer after primary in situ therapy.

The aim of this study was to evaluate the diagnostic value of a hybrid (111)In-capromab pendetide fused computed tomography (CT) scan in detecting seminal vesicle invasion (SVI) in the setting of recurrent prostate cancer following primary in situ therapy. The study population comprised 59 patients, who biochemically failed primary in situ treatment based on American Society for Therapeutic Radiology and Oncology criteria. The patients underwent an (111)In-capromab pendetide/CT scan at the time of biochemical failure with a prostate (12-core) and seminal vesicle (SV) (8-core) biopsy. The diagnostic properties of the scan and magnetic resonance imaging (MRI) in detecting SVI compared to an SV biopsy were calculated. In total, eight (14%) patients had a positive SV biopsy after primary in situ prostate cancer treatment. Nine (15%) patients had positive uptake of the scan in the SV. When comparing the SV scan results to the SV biopsy, the sensitivity, specificity, positive predictive value, and negative predictive value were 37.5%, 88.2%, 33.3%, and 90.0% (95% confidence interval: 0.44-0.81), respectively. In contrast, the ability of MRI to detect SVI was 50.0%, 81.3%, 40.0%, and 86.7% (95% confidence interval: 0.46-0.85), respectively. Although the sensitivity and positive predictive value of the (111)In-capromab pendetide/CT scan are low, its specificity and negative predictive value are high. Based on these findings, the ability of the (111)In-capromab pendetide/CT scan to detect SVI seems to be comparable with MRI.
Authors
Kimura, M; Tsivian, M; Mouraviev, V; Mayes, JM; Price, MM; Bannister, MC; Madden, JF; Wong, TZ; Polascik, TJ
MLA Citation
Kimura, Masaki, et al. “Utilization of (111)In-Capromab pendetide SPECT-CT for detecting seminal vesicle invasion with recurrent prostate cancer after primary in situ therapy..” Int J Urol, vol. 16, no. 12, Dec. 2009, pp. 971–75. Pubmed, doi:10.1111/j.1442-2042.2009.02413.x.
URI
https://scholars.duke.edu/individual/pub727368
PMID
19843189
Source
pubmed
Published In
Int J Urol
Volume
16
Published Date
Start Page
971
End Page
975
DOI
10.1111/j.1442-2042.2009.02413.x

The Association between RT-induced Changes in Lung Tissue Density and Global Lung Function

Authors
Ma, J; Zhang, J; Zhou, S; Hubbs, JL; Foltz, RJ; Hollis, DR; Light, KL; Wong, TZ; Kelsey, CR; Marks, LB
MLA Citation
Ma, J., et al. “The Association between RT-induced Changes in Lung Tissue Density and Global Lung Function.” International Journal of Radiation Oncology*Biology*Physics, vol. 72, no. 1, Elsevier BV, 2008, pp. S456–S456. Crossref, doi:10.1016/j.ijrobp.2008.06.1848.
URI
https://scholars.duke.edu/individual/pub888972
Source
crossref
Published In
International Journal of Radiation Oncology, Biology, Physics
Volume
72
Published Date
Start Page
S456
End Page
S456
DOI
10.1016/j.ijrobp.2008.06.1848

Initial patient study with dedicated dual-modality SPECT-CT mammotomography

Dual-modality SPECT-CT dedicated breast imaging offers great promise in the detection/staging of cancer and the monitoring of treatment therapies. The sequential acquisition with emission (nuclear) and transmission (x-ray) 3D imaging systems can aid in localizing the radioactive uptake of a tumor from the emission image by using the anatomical structure from the transmission image as a roadmap. Both independent SPECT and CT subsystems are mounted onto a single gantry that rotates around the vertical axis of a pendant, uncompressed breast. To evaluate the feasibility of this dedicated system, geometric phantoms and breast phantoms using fiducial markers were acquired to study the sampling and resolution properties and demonstrate the fusion of the functional-anatomical images. In addition, a preliminary investigation on the clinical performance of the system was done by imaging two women with confirmed breast cancer: one on the independent SPECT system and the other on the SPECT-CT system. Further patient hybrid imaging studies are in progress. This compact dedicated SPECT-CT system is capable of non-invasively providing complementary functional and anatomical fully-3D activity distribution information of the breast, and has the potential to help further enhance the visual and quantitative information over the independent systems. © 2007 IEEE.
Authors
Madhav, P; Cutler, SJ; Perez, KL; Crotty, DJ; McKinley, RL; Wong, TZ; Tornai, MP
MLA Citation
Madhav, P., et al. “Initial patient study with dedicated dual-modality SPECT-CT mammotomography.” Ieee Nuclear Science Symposium Conference Record, vol. 5, Dec. 2007, pp. 3781–87. Scopus, doi:10.1109/NSSMIC.2007.4436945.
URI
https://scholars.duke.edu/individual/pub802510
Source
scopus
Published In
Ieee Nuclear Science Symposium Conference Record
Volume
5
Published Date
Start Page
3781
End Page
3787
DOI
10.1109/NSSMIC.2007.4436945